The HNF1A Hanging Chair transcription factor, implicated in the regulation of pancreatic beta cells, as well as in glucose and lipid metabolism, is responsible for type 3 maturity-onset diabetes of the young (MODY3).HNF1A is also involved in increased susceptibility to polygenic forms of diabetes, such as type 2 diabetes (T2D) and gestational diabe
Abstract A convenient and efficient solvent-free, facile, one-pot three-component graphene oxide catalysed approach has been described for the synthesis of chromeno-[4,3-b]quinolin-6-one derivatives from 4-hydroxycoumarin with aldehydes and aromatic Office Chairs amines.Graphene oxide (GO) has proved to be a new class of heterogeneous carbocatalyst
ABSTRACT In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120.A fluorescent KSK120 analogue was synthesized and observed to be associated with the C.trachomatis surface, suggesting that its target is bacterial.We isolated KSK120-resistant strains a
Chronic liver disease incidence is increasing among children worldwide due to a multitude of epidemiological changes.Most of these chronic insults to the pediatric liver progress to fibrosis and cirrhosis to different degrees.Liver and immune physiology differs significantly in children from adults.Because most of pediatric liver diseases have no d
Abstract.In the downstream part of the spillway building, especially in the flood way, occurs phenomenon of changing flow conditions from super critical to sub critical which causes a hydraulic jump and used by energy absorbers to reduce flow energy.The hydraulic jump in the floodway causes scouring of the bottom, particularly in the unprotected do